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Yerba santa is commonly used as a treatment for respiratory conditions. Because of its expectorant properties, it may be used to relieve coughs from respiratory conditions such as chronic bronchitis and colds. (An expectorant helps to loosen and remove mucus from breathing passages. )

Yerba Santa tea may be made from yerba santa by chopping or crushing about one teaspoonful of fresh or dried leaves, pouring about 8 ounces of boiling water over them, and letting them soak for 30 minutes. The solid particles are strained out before drinking the tea, which may be taken up to three times a day. Due to its pleasant taste, yerba santa tea may be added to other herbal teas to improve the flavor.

"The natives of the American Southwest have used yerba santa for generations, introducing it to the Spanish who came to the area in the late 18th century. For medicine, yerba santa leaves are gathered after the plant blooms. Leaves are used either fresh or dried and either by mouth or applied to the skin. Yerba santa's pleasant taste is often used to disguise bitter-tasting medicines."